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Hippocampal-neocortical interactions in memory formation, consolidation, and reconsolidation.
Annual Review of Psychology ( IF 23.6 ) Pub Date : 2010-01-01 , DOI: 10.1146/annurev.psych.093008.100523
Szu-Han Wang 1 , Richard G M Morris
Affiliation  

This review, focusing on work using animals, updates a theoretical approach whose aim is to translate neuropsychological ideas about the psychological and anatomical organization of memory into the neurobiological domain. It is suggested that episodic-like memory consists of both automatic and controlled components, with the medial temporal mediation of memory encoding including neurobiological mechanisms that are primarily automatic or incidental. These ideas, in the cognitive and behavioral domain, are linked to neurophysiological ideas about cellular consolidation concerning synaptic potentiation, particularly the relationship between protein synthesis-dependent long-term changes and shorter-lasting post-translational mechanisms. Ideas from psychology about mental schemas are considered in relation to the phenomenon of systems consolidation and, specifically, about how prior knowledge can alter the rate at which consolidation occurs. Finally, the hippocampal-neocortical interactions theory is updated in relation to reconsolidation, a process that enables updating of stored memory traces in response to novelty.

中文翻译:

记忆形成、巩固和再巩固中的海马-新皮质相互作用。

这篇综述侧重于使用动物的工作,更新了一种理论方法,其目的是将关于记忆的心理和解剖组织的神经心理学思想转化为神经生物学领域。有人提出,情景样记忆由自动和受控成分组成,记忆编码的中间时间中介包括主要是自动或偶然的神经生物学机制。在认知和行为领域,这些想法与关于突触增强的细胞整合的神经生理学观点有关,尤其是依赖于蛋白质合成的长期变化与持续时间较短的翻译后机制之间的关系。心理学关于心理图式的想法被认为与系统整合现象有关,并且,具体来说,关于先验知识如何改变合并发生的速度。最后,海马-新皮质相互作用理论与再巩固有关,这是一个能够更新存储的记忆痕迹以响应新奇事物的过程。
更新日期:2009-12-03
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