Prostaglandin endoperoxidase synthase 2 is a key regulator of inflammation and may play a role in prostate carcinogenesis. The polymorphism, -899G>C (rs20417), alters a transcription factor-binding site and is associated with a reduced risk of colorectal adenoma. We tested the hypothesis that rs20417 may influence prostate cancer risk, using a large case-control study (n(cases)=1608, n(controls)=3058). We found no evidence that rs20417 alters prostate cancer risk (odds ratio (OR(CC & GC v GG)=1.05, 95% confidence interval (CI)=0.91-1.20). A meta-analysis of three studies also found little evidence that rs20417 alters risk (pooled OR(CC & GC v GG)=1.04, 95% CI=0.93-1.17), making it unlikely that rs20417 contributes in any major way to prostate cancer aetiology.

中文翻译：

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PTGS2-899G>C 和前列腺癌风险：基于人群的巢式病例对照研究 (ProtecT) 和荟萃分析的系统评价。

前列腺素内过氧化物酶合酶 2 是炎症的关键调节因子，可能在前列腺癌发生中发挥作用。多态性 -899G>C (rs20417) 改变了转录因子结合位点，并与结直肠腺瘤风险降低有关。我们使用大型病例对照研究（n(cases)=1608，n(controls)=3058）检验了 rs20417 可能影响前列腺癌风险的假设。我们没有发现 rs20417 改变前列腺癌风险的证据（比值比（OR(CC & GC v GG)=1.05，95% 置信区间 (CI)=0.91-1.20）。对三项研究的荟萃分析也发现几乎没有证据表明rs20417 改变风险（合并 OR(CC & GC v GG)=1.04，95% CI=0.93-1.17），使得 rs20417 不太可能以任何主要方式导致前列腺癌病因。