Over the past ten years, investigators have shown that T lymphocytes can recognize not only peptides in the context of MHC class I and class II molecules but also foreign and self-lipids in association with the nonclassical MHC class I molecules the CD1 proteins. We describe the events that have led to the discovery of the role of CD1 molecules, their pattern of intracellular trafficking, and their ability to sample different intracellular compartments for self- and foreign lipids. Structural and functional aspects of lipid presentation by CD1 molecules are presented in the context of the function of CD1-restricted T cells in antimicrobial responses, antitumor immunity, and the regulation of the tolerance and autoimmunity immunoregulatory axis. Particular emphasis is on invariant NKT (iNKT) cells and their ability to modulate innate and adaptive immune responses.

中文翻译：

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CD1 分子脂质结合的结构和功能方面。

在过去的十年中，研究人员表明，T 淋巴细胞不仅可以识别 MHC I 类和 II 类分子背景下的肽，还可以识别与非经典 MHC I 类分子 CD1 蛋白相关的外源和自身脂质。我们描述了导致发现 CD1 分子的作用、它们的细胞内运输模式以及它们对不同细胞内隔室进行自我和外来脂质采样的能力的事件。CD1 分子脂质呈递的结构和功能方面是在 CD1 限制性 T 细胞在抗菌反应、抗肿瘤免疫以及耐受性和自身免疫免疫调节轴的调节中的功能的背景下提出的。