Many major human neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), display axonal pathologies including abnormal accumulations of proteins and organelles. Such pathologies highlight damage to the axon as part of the pathogenic process and, in particular, damage to transport of cargoes through axons. Indeed, we now know that disruption of axonal transport is an early and perhaps causative event in many of these diseases. Here, we review the role of axonal transport in neurodegenerative disease.

中文翻译：

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轴突运输在神经退行性疾病中的作用。

许多主要的人类神经退行性疾病，包括阿尔茨海默病、帕金森病和肌萎缩侧索硬化 (ALS)，都表现出轴突病变，包括蛋白质和细胞器的异常积累。这种病理突出了轴突损伤作为致病过程的一部分，特别是通过轴突对货物运输造成的损害。事实上，我们现在知道轴突运输的中断是许多这些疾病的早期并且可能是致病事件。在这里，我们回顾了轴突运输在神经退行性疾病中的作用。