TBX2 and TBX3 are transcription factors that belong to the T-box family, members of which play important roles during mammalian embryogenesis. Mutations in T-box genes have been linked to several human genetic disorders and increasing evidence suggests that Tbx2 and Tbx3 may play a key role in cancer. The primary functions of Tbx2 and Tbx3 remain poorly defined, mainly because of their widespread expression in several tissues and their multiple potential roles in morphogenesis, organogenesis and cell-fate commitment. Here, we describe in detail the expression of Tbx2 and Tbx3 in the developing hypothalamic-pituitary axis. Localized transcripts can be detected during the early stages of pituitary commitment. Expression of Tbx2 is restricted to the infundibular region of the ventral diencephalon (VD) at all ages examined, whereas Tbx3 can be detected in both the VD and Rathke's pouch, the precursor of the anterior pituitary. Outside the developing hypophyseal organ novel sites of Tbx3 and Tbx2 expression include migrating branchiomotor (BM) and visceromotor (VM) neurons in the hindbrain, neuroepithelial cells of the developing tongue (Tbx3) as well as the developing blood vessel network (Tbx2).

中文翻译：

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Tbx2 和 Tbx3 在发育中的下丘脑-垂体轴中的表达。

TBX2 和 TBX3 是属于 T-box 家族的转录因子，其成员在哺乳动物胚胎发生过程中起重要作用。T-box 基因的突变与几种人类遗传疾病有关，越来越多的证据表明 Tbx2 和 Tbx3 可能在癌症中起关键作用。Tbx2 和 Tbx3 的主要功能仍未明确，主要是因为它们在多种组织中广泛表达以及它们在形态发生、器官发生和细胞命运承诺中的多种潜在作用。在这里，我们详细描述了 Tbx2 和 Tbx3 在发育中的下丘脑-垂体轴中的表达。在垂体承诺的早期阶段可以检测到本地化的成绩单。Tbx2 的表达仅限于所有年龄检查的腹侧间脑 (VD) 的漏斗区，而 Tbx3 可以在 VD 和 Rathke 囊（垂体前叶的前体）中检测到。在发育中的垂体器官外，Tbx3 和 Tbx2 表达的新位点包括后脑中的迁移性分支运动 (BM) 和内脏运动 (VM) 神经元、发育中舌的神经上皮细胞 (Tbx3) 以及发育中的血管网络 (Tbx2)。