FMR1 premutations are known to be associated with premature ovarian failure (POF), but the underlying mechanism is unknown. We present evidence for a nonlinear association between menopause age and premutation size suggesting that premutations in the mid-size range are at greatest risk for POF, while larger premutations are at lower risk.

中文翻译：

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FMR1预突变载体中CGG重复数与绝经年龄之间的非线性关联。

已知FMR1突变与卵巢早衰（POF）有关，但是其潜在机制尚不清楚。我们提供了绝经年龄与预突变大小之间非线性关联的证据，表明中等大小范围内的预突变发生POF的风险最高，而较大的预突变发生的风险较低。