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Specimen Temperature Detection on a Clinical Laboratory Pre-Analytic Automation Track: Implications for Direct-from-Track Total Laboratory Automation (TLA) Systems.
SLAS Technology: Translating Life Sciences Innovation ( IF 2.5 ) Pub Date : 2019-10-08 , DOI: 10.1177/2472630319881999
Caleb S Roundy 1 , David C Lin 1, 2, 3 , Paul J Klopping 1 , Ammon T Ence 1 , Anthony C Krezel 1 , Jonathan R Genzen 1, 2
Affiliation  

Clinical laboratory regulations require temperature monitoring of facilities, reagent and specimen storage, as well as temperature-dependent equipment. Real-time specimen temperature detection has not yet been integrated into total laboratory automation (TLA) solutions. An infrared (IR) pyrometer was paired with a complementary metal oxide semiconductor (CMOS) laser sensor and connected to an embedded networked personal computer (PC) to create a modular temperature detection unit for closed, moving clinical laboratory specimens. Accuracy of the detector was assessed by comparing temperature measurements to those obtained from thermocouples connected to battery-operated data loggers. The temperature detector was then installed on a pre-analytic laboratory automation system to assess specimen temperature before and after processing on an integrated thawing and mixing (T/M) robotic workcell. The IR temperature detector was able to accurately record temperature of closed, moving specimens on a pre-analytic automation system. The effectiveness of the T/M workcell was independently verified using the temperature detector. Specimen reroute on the pre-analytic automation track was identified as a potential risk for frozen specimens being inadvertently delivered to future, connected instrumentation. Automated IR temperature detection can be used to verify specimen temperature prior to instrument loading and/or sampling. Such systems could be used to prevent frozen specimens from being inadvertently loaded onto analytical instrumentation in TLA solutions.

中文翻译:

临床实验室分析前自动化轨道上的标本温度检测:直接追踪整个实验室自动化(TLA)系统的含义。

临床实验室法规要求对设施,试剂和样本存储以及温度相关设备进行温度监控。实时标本温度检测尚未集成到整体实验室自动化(TLA)解决方案中。红外高温计与互补金属氧化物半导体(CMOS)激光传感器配对,并连接到嵌入式联网个人计算机(PC),以创建用于封闭,移动的临床实验室标本的模块化温度检测单元。通过将温度测量值与从连接到电池供电的数据记录器的热电偶获得的温度测量值进行比较,可以评估探测器的准确性。然后将温度检测器安装在预分析实验室自动化系统上,以在集成解冻和混合(T / M)机器人工作单元上进行处理之前和之后评估样品温度。红外温度检测器能够在预分析自动化系统上准确记录封闭的移动样本的温度。T / M工作单元的有效性使用温度检测器独立验证。样品在分析前的自动化轨道上的重新路线被确定为将冷冻样品无意中交付给未来连接的仪器的潜在风险。自动红外温度检测可用于在仪器加载和/或采样之前验证样品温度。
更新日期:2020-04-10
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