Connections in nervous systems are disproportionately concentrated on a small subset of neural elements that act as network hubs. Hubs have been found across different species and scales ranging from C. elegans to mouse, rat, cat, macaque, and human, suggesting a role for genetic influences. The recent availability of brain-wide gene expression atlases provides new opportunities for mapping the transcriptional correlates of large-scale network-level phenotypes. Here we review studies that use these atlases to investigate gene expression patterns associated with hub connectivity in neural networks and present evidence that some of these patterns are conserved across species and scales.

中文翻译：

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揭示神经网络中集线器连接的转录相关性。

神经系统中的连接不成比例地集中在充当网络枢纽的一小部分神经元件上。从秀丽隐杆线虫到小鼠、大鼠、猫、猕猴和人类，不同物种和规模都发现了中枢，这表明​​遗传影响发挥了作用。最近全脑基因表达图谱的出现为绘制大规模网络水平表型的转录相关性提供了新的机会。在这里，我们回顾了使用这些图集来研究与神经网络中的中枢连接相关的基因表达模式的研究，并提供了证据表明其中一些模式在物种和尺度上是保守的。