Relying on their ease of isolation and remarkable tissue reparative/regenerative potential, dental pulp stem/progenitor cells (DPSCs) gained pronounced importance in the field of regenerative dentistry. Though inflammation is classically considered the reason for the damage of the dentin-pulpal complex, it continues to be an essential stage of any dentin-pulpal tissue repair or regeneration procedures. During their performance of a pulpal tissue repair or regeneration actions, DPSCs interact with their inflammatory microenvironment locally, possibly influencing their fate and the result of any DPSCs-mediated dentin-pulpal reparative/regenerative endeavor. Hence, this review aims at comprehensively elaborating on these complex interactions of DPSCs with their local pulpal inflammatory microenvironment, particularizing on the inflammatory aspects, affecting DPSCs' stemness, homing/migration, proliferation, differentiation as well as immunomodulation characteristics, and the potentially fundamental intracellular processes involved and their anticipated association with the noncanonical as well as canonical Wnt/β-Catenin intracellular signaling. Impact Statement This review particularizes on the current state of knowledge on the complex interrelation between dental pulp stem/progenitor cells and their pulpal inflammatory microenvironment; elaborates on inflammation aspects affecting their stemness, proliferation, migration/homing, differentiation and immunomodulation characteristics, and the fundamental intracellular processes involved and their anticipated association with the canonical and noncanonical Wnt pathways. All these aspects could significantly affect the dento-pulpal regenerative therapeutic approaches in vivo.

中文翻译：

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牙髓干/祖细胞介导的炎症再生轴。

依靠其易于分离和显着的组织修复/再生潜能，牙髓干/祖细胞（DPSC）在再生牙科领域中获得了显着的重要性。尽管炎症通常被认为是造成牙本质-牙髓复合体受损的原因，但炎症仍然是任何牙本质-牙髓组织修复或再生程序的重要阶段。在进行牙髓组织修复或再生的过程中，DPSCs与炎症微环境局部相互作用，可能影响其命运以及任何DPSCs介导的牙本质-修复/再生努力的结果。因此，本综述旨在全面阐述DPSC与局部牙髓炎症微环境的这些复杂相互作用，特别是炎症方面，影响DPSC的干，归巢/迁移，增殖，分化以及免疫调节特性，并涉及潜在的基本细胞内过程，以及它们与非典型以及经典Wnt /β-Catenin细胞内信号传导的关联。影响陈述这篇综述专门介绍了牙髓干/祖细胞与其牙髓炎性微环境之间复杂的相互关系的知识的现状。阐述炎症影响其干，增殖，迁移/归巢，分化和免疫调节特性的方面，以及涉及的基本细胞内过程以及它们与经典和非经典Wnt途径的关联。