BACKGROUND We investigated whether metabolic risk factors in one spouse were associated with an excessive risk of type 2 diabetes in the other. METHODS The study cohort (1999-2018) included 1833 men and 1952 women, aged ≥ 20 years with information on both their own and their spouse's diabetes status and metabolic risk factors including body mass index (BMI), waist circumference, systolic and diastolic blood pressure, triglyceride to high-density lipoprotein cholesterol ratio, and type 2 diabetes. The associations between spousal metabolic risk factors and type 2 diabetes were estimated using Cox regression models adjusted for the three nested sets of covariates. RESULTS We found 714 (360 men and 354 women) incident cases of type 2 diabetes, after more than 15 years of follow-up. Among women, having a husband with diabetes was associated with a 38% (hazard ratio (HR) 1.38; 95% confidence interval (CI) 1.03, 1. 84) increased risk of type 2 diabetes, adjusted for age, socioeconomic status, individual's own value of the respective spousal exposure variable, family history of diabetes, and physical activity level. After further adjustment for the woman's own BMI level, the husband's diabetes was associated with 23% (HR 1.23; 0.92, 1.64) higher risk of type 2 diabetes in wives, values which did not reach statistical significance. No significant associations were found between spousal metabolic risk factors and incidence of type 2 diabetes among index men. CONCLUSION We found a sex-specific effect of spousal diabetes on the risk of type 2 diabetes. Having a husband with diabetes increased an individual's risk of type 2 diabetes. Our results might contribute to the early detection of individuals at high risk of developing type 2 diabetes, particularly, in women adversely affected by their partner's diabetes.

中文翻译：

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配偶代谢危险因素与2型糖尿病发生率之间关联的性别差异：伊朗人群的纵向研究。

背景我们调查了一个配偶中的代谢危险因素是否与另一人中的2型糖尿病的过度危险相关。方法该研究队列（1999-2018年）包括年龄≥20岁的1833名男性和1952名女性，其自身和配偶的糖尿病状况以及包括身体质量指数（BMI），腰围，收缩压和舒张压的代谢危险因素的信息压力，甘油三酸酯与高密度脂蛋白胆固醇的比率以及2型糖尿病。配偶代谢危险因素与2型糖尿病之间的关联使用针对三套嵌套的协变量调整的Cox回归模型进行估算。结果经过15年以上的随访，我们发现了714例（360例男性和354例女性）2型糖尿病事件。在女性中 丈夫患有糖尿病会导致2％糖尿病的患病风险增加38％（危险比（HR）1.38； 95％置信区间（CI）1.03，1. 84），该年龄因年龄，社会经济地位以及个人的自身价值而调整各自的配偶暴露变量，糖尿病家族史和体育锻炼水平。进一步调整妇女自身的BMI水平后，丈夫的糖尿病与妻子的2型糖尿病风险增加23％（HR 1.23; 0.92，1.64）相关，但这一数值未达到统计学意义。在配偶代谢危险因素与2型糖尿病发生率之间没有显着相关性。结论我们发现，配偶糖尿病对2型糖尿病的风险具有性别特异性。丈夫患有糖尿病会增加一个人的生命 患有2型糖尿病的风险。我们的结果可能有助于及早发现罹患2型糖尿病的高风险个体，尤其是在其伴侣的糖尿病不利影响的女性中。