Background: Chronic Liver Disorders (CLD), caused by the lifestyle patterns like alcoholism or by non-alcoholic fatty liver disease or because of virus-mediated hepatitis, affect a large population fraction across the world. CLD progresses into end-stage diseases with a high mortality rate. Liver transplant is the only approved treatment available for such end-stage disease patients. However, the number of liver transplants is limited due to the limited availability of suitable donors and the extremely high cost of performing the procedure. Under such circumstances, Stem Cell (SC) mediated liver regeneration has emerged as a potential therapeutic alternative approach.

背景：由诸如酒精中毒或非酒精性脂肪肝等生活方式引起的慢性肝病（CLD），或由病毒介导的肝炎引起的慢性肝病，影响了全世界的大部分人口。CLD会发展为高死亡率的终末期疾病。肝移植是用于此类终末期疾病患者的唯一批准的治疗方法。然而，由于合适的供体的可用性有限以及执行该过程的极高成本，肝脏移植的数量受到限制。在这种情况下，干细胞（SC）介导的肝再生已成为一种潜在的治疗替代方法。