OBJECTIVES Postoperative patients with tetralogy of Fallot (TOF) are often compromised by chronic pulmonary regurgitation and chronic right ventricular volume load. We sought to determine whether pulmonary regurgitation (PR) would affect right and left ventricle (RV and LV) strain. MATERIALS AND METHODS This cross-sectional analysis included 40 patients who had TOF with surgical repair, with an average follow-up period of 11.8 ± 3.0 years. Altogether, 44 healthy volunteers with similar age and gender distribution were recruited. A cardiovascular magnetic resonance imaging study with feature tracking analysis was performed on all patients and controls. RESULTS RV peak longitudinal strain was increased in TOF patients with PR > 30 ml/m2 when compared to those with PR < 30 ml/m2 (- 22.5% ± 2.7% vs - 19.7% ± 3.5%, p = 0.018) and controls (p = 0.007). PR volume correlated with peak RV longitudinal strain (R = - 0.37, p = 0.030) and peak RV longitudinal strain rate (systolic: R = 0.37, p = 0.03; diastolic: R = 0.39, p = 0.021). The peak RV circumferential strain, from base to apex, increased more than in healthy controls (apex-base difference 7.6% ± 4.2% vs 3.3% ± 2.4%, p < 0.0001). CONCLUSIONS Pediatric patients with TOF and a severe pulmonary regurgitation show an enhanced longitudinal strain when compared to patients with milder regurgitation or to control subjects. In addition, mean RV circumferential strain of the patients is significantly enhanced compared to healthy individuals.

中文翻译：

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患有法洛氏四联症的青少年严重肺关闭不全导致纵向张力增加。

目的术后患有法洛四联症（TOF）的患者通常会受到慢性肺返流和慢性右心室容积负荷的影响。我们试图确定肺返流（PR）是否会影响左右心室（RV和LV）应变。材料与方法这项横断面分析包括40例接受TOF手术修复的患者，平均随访时间为11.8±3.0年。总共招募了44名年龄和性别分布相似的健康志愿者。对所有患者和对照者进行了带有特征跟踪分析的心血管磁共振成像研究。结果与PR <30 ml / m2的TOF患者相比，PR> 30 ml / m2的TOF患者RV峰值纵向应变增加（-22.5％±2.7％vs-19.7％±3.5％，p = 0。018）和对照（p = 0.007）。PR量与RV峰值纵向应变（R =-0.37，p = 0.030）和RV峰值峰值应变率（收缩压：R = 0.37，p = 0.03;舒张压：R = 0.39，p = 0.021）相关。从基部到根尖，RV的峰值圆周应变比健康对照者增加更多（根基差异为7.6％±4.2％对3.3％±2.4％，p <0.0001）。结论与轻度返流患者或对照组相比，TOF合并严重肺返流的儿科患者的纵向应变增加。另外，与健康个体相比，患者的平均RV圆周应变显着增强。021）。从基部到根尖，RV的峰值圆周应变比健康对照者增加更多（根基差异为7.6％±4.2％对3.3％±2.4％，p <0.0001）。结论与轻度返流患者或对照组相比，TOF合并严重肺返流的儿科患者的纵向应变增加。另外，与健康个体相比，患者的平均RV圆周应变显着增强。021）。从基部到根尖，RV的峰值圆周应变比健康对照者增加更多（根基差异为7.6％±4.2％对3.3％±2.4％，p <0.0001）。结论与轻度返流患者或对照组相比，TOF合并严重肺返流的儿科患者的纵向应变增加。另外，与健康个体相比，患者的平均RV圆周应变显着增强。