Physical inactivity, prolonged sedentary behaviors, and use of visual display terminals as potential risk factors for dry eye disease: JPHC-NEXT study.,The Ocular Surface

当前位置： X-MOL 学术 › Ocul. Surf. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Physical inactivity, prolonged sedentary behaviors, and use of visual display terminals as potential risk factors for dry eye disease: JPHC-NEXT study.
The Ocular Surface ( IF 5.9 ) Pub Date : 2019-09-26 , DOI: 10.1016/j.jtos.2019.09.007
Akiko Hanyuda ₁ , Norie Sawada ₂ , Miki Uchino ₃ , Motoko Kawashima ₃ , Kenya Yuki ₃ , Kazuo Tsubota ₃ , Kazumasa Yamagishi ₄ , Hiroyasu Iso ₅ , Nobufumi Yasuda ₆ , Isao Saito ₇ , Tadahiro Kato ₈ , Yasuyo Abe ₉ , Kazuhiko Arima ₉ , Kozo Tanno ₁₀ , Kiyomi Sakata ₁₀ , Taichi Shimazu ₂ , Taiki Yamaji ₂ , Atsushi Goto ₂ , Manami Inoue ₂ , Motoki Iwasaki ₂ , Shoichiro Tsugane ₂ ,

Affiliation

Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Department of Public Health, Kochi University Medical School, Kochi, Japan.
Department of Public Health and Epidemiology, Faculty of Medicine, Oita University, Oita, Japan.
Center for Education and Educational Research, Faculty of Education, Ehime University, Ehime, Japan.
Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Department of Hygiene and Preventive Medicine, School of Medicine, Iwate Medical University, Iwate, Japan.

Purpose

This population-based, cross-sectional study was performed to assess the influence of life-style modalities, including physical activity, sedentary behaviors, and visual display terminal (VDT) use, on the prevalence of dry eye disease (DED).

Methods

The study included a total of 102,582 participants aged 40–74 years, from the Japan Public Health Center-based Prospective Study for the Next Generation, a large nationwide prospective ongoing Japanese cohort study. Logistic regression analyses were used to investigate the relationship of total and leisure-time physical activity, duration of sedentary behaviors, and VDT use (hours/day) with DED.

Results

Among 47,346 men and 55,236 women, 25,234 (8315 males and 16,919 females) cases of DED were documented. Total physical activity was significantly related to decreased DED in both sexes; for the highest vs. lowest total physical activity quartiles, the multivariable-adjusted odds ratios (ORs) for DED were 0.90 (95% confidence interval [CI], 0.84–0.97; P_trend<0.03) and 0.91 (95% CI, 0.86–0.95; P_trend<0.001) for men and women, respectively. Conversely, prolonged sedentary behaviors and VDT use had significantly higher prevalence of DED in both sexes (P_trend<0.001). Notably, the favorable effect of total physical activity on decreased DED in women was more prevalent with prolonged VDT use (≥2 h/day) (P_interaction<0.01). In men, the duration of VDT use or sitting was a significant modifier of the inverse relationship between leisure-time physical activity and DED (P_interaction<0.05).

Conclusions

Physical inactivity, prolonged sedentary behaviors, and use of VDT were related to increased susceptibility to DED among middle-aged to older Japanese adults.

中文翻译：

缺乏运动，久坐不动的行为以及使用视觉显示终端作为干眼症的潜在危险因素：JPHC-NEXT研究。

目的

这项基于人群的横断面研究旨在评估生活方式（包括体育活动，久坐行为和视觉显示终端（VDT）使用）对干眼症（DED）患病率的影响。

方法

该研究包括来自日本公共卫生中心的“下一代前瞻性研究”，这是一项在全国范围内进行的大型前瞻性日本队列研究，总计102,582名年龄在40-74岁的参与者。使用Logistic回归分析来调查总运动量和休闲时间的体育活动，久坐行为的持续时间以及VDT与DED的使用（小时/天）之间的关系。

结果

在47,346名男性和55,236名女性中，记录了25,234例DED病例（8315例男性和16,919例女性）。男女双方的总体育活动与DED的降低显着相关。对于最高总运动量与最低总运动量四分位数，DED的多变量调整后的优势比（OR）为0.90（95％置信区间[CI]，0.84-0.97； P_趋势<0.03）和0.91（95％CI，0.86） –0.95；男性和女性的P_趋势<0.001）。相反，久坐行为和VDT的使用在两性中的DED患病率明显更高（P_趋势<0.001）。值得注意的是，长期使用VDT（≥2 h / day），总体体育锻炼对女性DED降低的有利影响更为普遍（P_相互作用<0.01）。在男性中，使用VDT或坐着的时间是休闲时间体力活动与DED的反比关系的重要调节器（P_交互作用<0.05）。