The activation of long-chain free fatty acids is the first step reaction of their usage in the cells and tissues, which are catalyzed by a family of enzymes called acyl-coenzyme A synthetases long-chain isoform (ACSL). The five ACSL enzymes identified in mammals are thought to have specific and differing functions. Among them, ACSL4 is a unique isozyme that preferentially catalyzes several polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA), and ACSL4 is thought to be an important isozyme for PUFA metabolism. Recent studies revealed that ACSL4 is involved in biological responses including inflammation, steroidogenesis, cell death, female fertility, and cancer. ACSL4 and its substrate PUFAs are thus likely to contribute to these responses. However, the roles of ACSL4 in PUFA metabolism are not fully understood. In this review, we describe the recent progress in ACSL4 research including the involvement of this enzyme in AA metabolism.

中文翻译：

---

酰基辅酶A合成酶ACSL4在花生四烯酸代谢中的作用。

长链游离脂肪酸的激活是它们在细胞和组织中使用的第一步反应，它们被称为酰基辅酶A的酶家族催化合成长链同种型（ACSL）。在哺乳动物中鉴定出的五种ACSL酶被认为具有特定且不同的功能。其中，ACSL4是独特的同工酶，可优先催化几种多不饱和脂肪酸（PUFA），例如花生四烯酸（AA），而ACSL4被认为是PUFA代谢的重要同工酶。最近的研究表明，ACSL4与生物学反应有关，包括炎症，类固醇生成，细胞死亡，女性生育力和癌症。因此，ACSL4及其底物PUFA可能有助于这些反应。但是，ACSL4在PUFA代谢中的作用尚未完全了解。在这篇评论中