Type III Interferons (IFNs) or lambda IFNs (IFN-λs or IFNLs) although are primarily antiviral cytokines, may have roles to play in shaping immune responses, including those during inflammation. Genetic variants within the IFNL locus have been shown to be associated with various inflammatory conditions in humans ranging from metabolic to autoimmune and allergic diseases. The mechanism behind these genetic associations is not clear. Appropriate data analysis methods and functional evidence should be complimentarily used to identify the causal variants and mechanisms.

中文翻译：

---

IFN-λs 与人类炎症性疾病的遗传关联仍然是一个难题。

III 型干扰素 (IFN) 或 λ IFNs (IFN-λs 或 IFNLs) 虽然主要是抗病毒细胞因子，但可能在形成免疫反应中发挥作用，包括炎症期间的免疫反应。已显示 IFNL 基因座内的遗传变异与人类的各种炎症状况有关，从代谢到自身免疫和过敏性疾病。这些遗传关联背后的机制尚不清楚。应互补地使用适当的数据分析方法和功能证据来识别因果变异和机制。