The purpose of this study was two-fold: I) to determine the pharmacokinetic profile of meloxicam (MLX) in geese after intravenous (IV) and oral (PO) administration and II) to assess tissue residues in muscle, heart, liver, lung, and kidney. Ten clinically normal female Bilgorajska geese were divided into two groups (treated, n = 8; control, n = 2). Group 1 underwent a 3-phase parallel study with a 1-week washout period. In phase I, animals received MLX (0.5 mg/kg) by IV administration; the blood was collected up to 48 hr. In phases II and III geese were treated orally at the same dosage for the collection of blood and tissue samples, respectively. Group 2 served as control. After the extraction procedure, a validated HPLC method with UV detection was used for plasma and organ analysis. The plasma concentrations were quantifiable up to 24 hr after both the administrations. The elimination phase of MLX from plasma was similar in both the administration groups. The clearance was slow (0.00975 L/hr*Kg), the volume of distribution small (0.0487 L/kg), and the IV half-life was 5.06 ± 2.32 hr. The average absolute PO bioavailability was 64.2 ± 24.0%. Residues of MLX were lower than the LOQ (0.1 µg/kg) in any tested tissue and at any collection time. The dosage used in this study achieved the plasma concentration, which provides analgesia in Hispaniolan Amazon parrots for 5 out of 24 hr after PO administration. MLX tissue concentrations were below the LOD of the assay in tissue (0.03 µg/ml). A more sensitive technique might be necessary to determine likely residue concentrations in tissue.

中文翻译：

---

Bilgorajska 鹅单次静脉注射和口服给药后美洛昔康的药代动力学特征。


本研究的目的有两个：I) 确定美洛昔康 (MLX) 在静脉注射 (IV) 和口服 (PO) 给药后在鹅体内的药代动力学特征；II) 评估肌肉、心脏、肝脏、肺中的组织残留和肾脏。十只临床正常的雌性 Bilgorajska 鹅被分为两组（治疗组，n = 8；对照组，n = 2）。第 1 组进行了 3 阶段平行研究，并有 1 周的清除期。在第一阶段，动物通过IV给药接受MLX（0.5mg/kg）；血液采集时间长达 48 小时。在第二阶段和第三阶段，分别以相同的剂量对鹅进行口服处理，以收集血液和组织样本。第 2 组作为对照组。提取程序后，使用经过验证的 HPLC 方法和 UV 检测进行血浆和器官分析。两次给药后 24 小时内血浆浓度均可定量。两个给药组中 MLX 从血浆中的消除阶段相似。清除缓慢（0.00975 L/hr*Kg），分布容积小（0.0487 L/kg），IV半衰期为5.06 ± 2.32 hr。 PO 的平均绝对生物利用度为 64.2 ± 24.0%。在任何测试组织和任何收集时间，MLX 残留量均低于 LOQ (0.1 µg/kg)。本研究中使用的剂量达到了血浆浓度，可以为西班牙亚马逊鹦鹉 PO 给药后 24 小时内的 5 小时提供镇痛作用。 MLX 组织浓度低于组织中测定的 LOD (0.03 µg/ml)。可能需要更灵敏的技术来确定组织中可能的残留浓度。