PURPOSE To compare the effects on ocular temperature and tear film parameters following a single application of a latent heat eyelid warming device at a range of temperature settings. METHODS Fifteen subjects were enrolled in a prospective, investigator-masked, randomised, cross-over trial. On separate days, participants were randomised to 10-minute application of a research latent heat device (Laboratoires Théa) at device temperature settings of 45 °C, 50 °C and 55 °C. Outer eyelid and corneal temperatures, tear film lipid layer grade, and non-invasive tear film breakup time (NIBUT) were measured at baseline and immediately after 10 min of device application. RESULTS Baseline measurements did not differ between treatment groups (all p > 0.05). Ocular temperatures, lipid layer grade and non-invasive tear film stability rose significantly following device application in all treatment groups (all p < 0.05). The 55 °C setting effected a mean ocular surface temperature rise in the order of +4 °C from baseline, which was 1.46 and 1.26 times greater than at the 45 °C and 50 °C temperature settings, respectively (all p < 0.05). Similarly, improvements in mean non-invasive tear film stability from baseline in the order of +7 s were observed, which were 2.43 and 1.66 times greater than those at the lower temperature settings of 45 °C and 50 °C, respectively (all p < 0.05). CONCLUSIONS At all temperature settings, the latent heat device resulted in clinically and statistically significant increases in ocular temperature, lipid layer grade, and non-invasive tear film stability. However, the 55 °C setting proved to be most effective at raising ocular temperature (in the order of +4 °C from baseline) and improving tear film stability.

中文翻译：

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潜热眼睑加温装置随温度设定变化的治疗曲线。

目的比较在温度设置范围内一次使用潜热眼睑加温装置后对眼温和泪膜参数的影响。方法15名受试者参加了一项前瞻性，研究者掩盖的随机交叉试验。在不同的日子，参与者被随机分配在设备温度设置为45°C，50°C和55°C的研究潜热设备（LaboratoiresThéa）中进行10分钟的治疗。在基线和设备使用10分钟后立即测量眼睑和角膜的外部温度，泪膜脂质层等级和非侵入性泪膜破裂时间（NIBUT）。结果治疗组之间基线测量无差异（所有p> 0.05）。眼温 在所有治疗组中使用器械后，脂质层等级和非侵入性泪膜稳定性显着提高（所有p <0.05）。在55°C的温度下，平均眼表温度比基线升高+4°C，分别比在45°C和50°C的温度下分别高1.46和1.26倍（所有p <0.05） 。同样，与基线相比，平均无创泪膜稳定性提高了约+7 s，分别比45°C和50°C的较低温度设置分别高2.43和1.66倍（所有p <0.05）。结论在所有温度设置下，潜热装置均会在临床和统计学上显着提高眼温，脂质层等级和非侵入性泪膜稳定性。然而，