Abstract Liposomes containing cholesterol and monophosphoryl lipid A (such as ALFQ and AS01B) are vaccine adjuvants. During construction of the formulations, addition of QS21 to nano-size (50–100 nm) liposomes resulted in extremely large (up to ∼30 µm) liposomes in ALFQ, but AS01B liposomes remained small nano-vesicles. Here, we show that saturation of phospholipid chains is essential for production of large liposomes by QS21.

中文翻译：

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添加 QS21 后，含胆固醇脂质体的纳米级到微米级转化需要饱和磷脂

摘要 含有胆固醇和单磷酰脂质A（如ALFQ和AS01B）的脂质体是疫苗佐剂。在制剂的构建过程中，将 QS21 添加到纳米级（50-100 nm）脂质体中会导致 ALFQ 中的脂质体非常大（高达 30 µm），但 AS01B 脂质体仍然是小纳米囊泡。在这里，我们表明磷脂链的饱和对于 QS21 生产大脂质体是必不可少的。