After macrophage recognises and phagocytoses the microorganism, their phagosome undergoes a maturation process, which creates a hostile environment for the bacterium. The lumen is acidified, and proteolysis occurs to kill and degrade pathogen for further antigen presentation. It is important to understand the association between the macrophage intracellular activities and the outcome of infection. Different methods have been developed to measure the phagosome dynamics of macrophages, but there are still limitations.

中文翻译：

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开发配体包被的珠子来测量巨噬细胞的抗菌活性

在巨噬细胞识别并吞噬微生物后，它们的吞噬体会经历一个成熟过程，这为细菌创造了一个恶劣的环境。管腔被酸化，发生蛋白水解以杀死和降解病原体以进一步呈递抗原。了解巨噬细胞细胞内活动与感染结果之间的关联很重要。已经开发了不同的方法来测量巨噬细胞的吞噬体动力学，但仍然存在局限性。