Although astroviruses are most commonly associated with acute gastrointestinal illness in humans, their ability to infect a broad range of hosts and cause a spectrum of disease makes them widespread and complex pathogens. The precise mechanisms that dictate the course of astrovirus disease have not been studied extensively but are likely driven by multifactorial host–microbe interactions. Recent insights from studies of animal astrovirus infections have revealed both beneficial and detrimental effects for the host. However, further in-depth studies are needed to fully explore the consequences of astrovirus-induced changes in the gut microenvironment as well as the role of the microbiota in astrovirus infection.

尽管星状病毒最常见于人类急性胃肠道疾病，但它们感染多种宿主并引起多种疾病的能力使其成为广泛而复杂的病原体。决定星状病毒病病程的确切机制尚未得到广泛研究，但可能是由多因素宿主与微生物相互作用驱动的。动物星状病毒感染研究的最新见解揭示了对宿主的有益和有害作用。但是，需要进一步深入研究，以充分探讨星状病毒引起的肠道微环境变化的后果以及微生物群在星状病毒感染中的作用。