Malignant mesothelioma (MM) is a rare tumor of serous surfaces that has a poor prognosis. Cancer is a multistage process by which cells undergo metabolic and behavioral changes that cause excessive and untimely proliferation. Asprosin (ASP) and meteorin-like (METRNL) are two peptides associated with glucose and energy metabolism. We used immunohistochemistry to investigate whether these peptides could be biomarkers for diagnosis and treatment of MM. We reviewed 30 cases of MM and 30 cases of reactive mesothelial hyperplasia (RMH); we used the cases with RMH as control group. The specimens were examined using immunohistochemical staining for ASP and METRNL. ASP and METRNL immunoreactivity was more prominent in the MM specimens than the RMH specimens. Therefore, ASP and METRNL potentially could be used as markers for differentiating MM from benign diseases.

中文翻译：

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新型脂联素，如proprosin和meteorin样，是否可以作为恶性间皮瘤的生物标志物？

恶性间皮瘤（MM）是一种浆液性表面罕见的肿瘤，预后较差。癌症是一个多阶段过程，细胞经历新陈代谢和行为变化，导致过度和不合时宜的增殖。Asprosin（ASP）和meteorin-like（METRNL）是与葡萄糖和能量代谢相关的两个肽。我们使用免疫组化研究了这些肽是否可能是诊断和治疗MM的生物标志物。我们回顾了30例MM和30例反应性间皮增生（RMH）；我们以RMH为对照组。使用免疫组织化学染色对标本进行ASP和METRNL检查。MM标本中的ASP和METRNL免疫反应性比RMH标本更突出。因此，