We present a novel method for higher order reconstruction of fetal diffusion MRI signal that enables detection of fiber crossings. We combine data-driven motion and intensity correction with super-resolution reconstruction and spherical harmonic parametrisation to reconstruct data scattered in both spatial and angular domains into consistent fetal dMRI signal suitable for further diffusion analysis. We show that intensity correction is essential for good performance of the method and identify anatomically plausible fiber crossings. The proposed methodology has potential to facilitate detailed investigation of developing brain connectivity and microstructure in-utero.

中文翻译：

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具有强度校正的胎儿扩散MRI的高阶球谐重构。

我们提出了一种新的方法，可对胎儿扩散MRI信号进行高阶重建，从而能够检测到纤维交叉。我们将数据驱动的运动和强度校正与超分辨率重建和球谐参数化相结合，以将散布在空间和角度域中的数据重建成适合进一步扩散分析的一致胎儿dMRI信号。我们表明强度校正对于该方法的良好性能至关重要，并且可以识别解剖学上合理的纤维交叉。所提出的方法学有可能促进详细研究发育中的大脑连通性和子宫内微观结构。