Metabolic syndrome (MetS) predisposes older adults to the development of frailty. However, previous studies have not explored factors that may influence the association between MetS and the risk of frailty in this population. Community-dwelling older adults (≥65 years of age) were prospectively identified and enrolled between 2013 and 2016. MetS and frailty were defined based on the American Association of Clinical Endocrinologists and Study of Osteoporotic Fractures criteria, respectively. Multiple logistic regression with frailty/prefrailty as the dependent variable was used to examine the relationship between MetS and frailty/prefrailty, supplemented by subgroup analyses of the influence of aging and chronic kidney disease (CKD). Among 2862 elderly (73.4 ± 6.7 years), 17.5% and 17.3%, respectively, had MetS and frailty/prefrailty, among whom 74 (2.6%) and 420 (14.7%) had frailty and prefrailty. The presence of MetS (odds ratio [OR] 2.53, p < 0.001), higher age (OR 1.05, p < 0.001), and CKD (OR 1.42, p = 0.006) were associated with a significantly higher risk of frailty/prefrailty. Furthermore, among those ≥80 years of age, the association between MetS and frailty/prefrailty disappeared (p = 0.329). Among those with CKD, the presence of MetS was significantly associated with a progressively higher risk of frailty/prefrailty (for stage 3 or higher and for stage 3b or higher, OR 6.4 and 12.4, p < 0.001 and = 0.009, respectively). In conclusion, aging and CKD modified the association between MetS and frailty. These findings may assist in devising case-specific care plans for elderly with MetS by refocusing our attention on those at high risk of developing frailty/prefrailty.

中文翻译：

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高龄和慢性肾脏病改变了社区居民中老年人的代谢综合征与虚弱之间的联系。

代谢综合症（MetS）使老年人容易出现虚弱。但是，先前的研究尚未探讨可能影响MetS与该人群虚弱风险之间关联的因素。在2013年至2016年之间对居住在社区中的老年人（≥65岁）进行了前瞻性鉴定和入组。MetS和虚弱人群分别根据美国临床内分泌学家协会和骨质疏松性骨折研究标准进行定义。以衰弱/虚弱为因变量的多元logistic回归用于检验MetS与衰弱/虚弱之间的关系，并辅以对衰老和慢性肾脏病（CKD）影响的亚组分析。在2862名老年人（73.4±6.7岁）中，有MetS和虚弱/脆弱的人分别占17.5％和17.3％，其中有74名（2.6％）和420名（14.7％）身体虚弱和脆弱。MetS的存在（赔率[OR]为2.53，p  <0.001），较高的年龄（OR 1.05，p  <0.001）和CKD（OR 1.42，p  = 0.006）与脆弱/脆弱的风险显着相关。此外，在≥80岁的人群中，MetS与虚弱/脆弱性之间的关联消失了（p  = 0.329）。在患有CKD的患者中，MetS的存在与体弱/脆弱的风险逐步升高显着相关（对于3期或更高，3b或更高阶段，或6.4和12.4，p <0.001和= 0.009）。总之，衰老和CKD改变了MetS与虚弱之间的联系。这些发现可以通过将我们的注意力重新集中在那些有发展为脆弱/脆弱性的高风险人群身上，来帮助制定针对MetS的老年人的针对特定病例的护理计划。