Estrogens influence nearly every aspect of hippocampal function, including memory formation. Although this research has traditionally focused on ovariectomized females, more recent work is providing insights into the ways in which estrogens regulate hippocampal function in both sexes. This review provides an overview of estrogenic regulation of hippocampal function in female and male rodents, with a particular emphasis on memory formation. Where applicable, we discuss the involvement of specific estrogen receptors and molecular mechanisms that mediate these effects. The review concludes by suggesting gaps in the literature that need to be filled to provide greater insights into potential sex differences in the effects of estrogens on hippocampal function.

雌激素几乎影响海马功能的各个方面，包括记忆形成。尽管传统上这项研究的重点是去卵巢的女性，但最近的工作为了解雌激素调节男女海马功能的方式提供了见识。这篇综述概述了雌性和雄性啮齿动物对海马功能的雌激素调节作用，尤其着重于记忆形成。在适用的情况下，我们讨论了特定雌激素受体的参与和介导这些作用的分子机制。总结通过建议文献中的空白来结束，以提供对雌激素对海马功能影响的潜在性别差异的更多见解。