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Live and let die: Hydrogen peroxide production by the commensal flora and its role in maintaining a symbiotic microbiome.
Molecular Oral Microbiology ( IF 2.8 ) Pub Date : 2018-07-15 , DOI: 10.1111/omi.12231
Sylvio Redanz 1 , Xingqun Cheng 2, 3 , Rodrigo A Giacaman 4 , Carmen S Pfeifer 1 , Justin Merritt 1 , Jens Kreth 1
Affiliation  

The majority of commensal oral streptococci are able to generate hydrogen peroxide (H2O2) during aerobic growth, which can diffuse through the cell membrane and inhibit competing species in close proximity. Competing H2O2 production is mainly dependent upon the pyruvate oxidase SpxB, and to a lesser extent the lactate oxidase LctO, both of which are important for energy generation in aerobic environments. Several studies point to a broad impact of H2O2 production in the oral environment, including a potential role in biofilm homeostasis, signaling, and interspecies interactions. Here, we summarize the current research regarding oral streptococcal H2O2 generation, resistance mechanisms, and the ecological impact of H2O2 production. We also discuss the potential therapeutic utility of H2O2 for the prevention/treatment of dysbiotic diseases as well as its potential role as a biomarker of oral health.

中文翻译:

生与死:共生菌群产生的过氧化氢及其在维持共生微生物组中的作用。

大多数普通的口服链球菌能够在有氧生长过程中产生过氧化氢(H 2 O 2),过氧化氢可以扩散穿过细胞膜并抑制竞争物种。竞争性的H 2 O 2产生主要取决于丙酮酸氧化酶SpxB,而在较小程度上取决于乳酸氧化酶LctO,这两者都对有氧环境中的能量产生至关重要。多项研究指出,H 2 O 2的产生在口腔环境中具有广泛的影响,包括在生物膜稳态,信号传导和种间相互作用中的潜在作用。在这里,我们总结了有关口腔链球菌H 2 O的最新研究H 2 O 2产生的2代,抗性机理和生态影响。我们还讨论了H 2 O 2在预防/治疗营养不良疾病方面的潜在治疗作用,以及其作为口腔健康生物标志物的潜在作用。
更新日期:2018-07-15
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