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Impacts of HBV rtH55R polymerase substitution on viral replication and rtM204I/V resistance to nucleoside/nucleotide antiviral drugs.
Antiviral Therapy ( IF 1.3 ) Pub Date : 2017-4-26 , DOI: 10.3851/imp3170
Kuan-Hui Xiang 1 , Cheng-Yu Zhao 1 , Shuai Wang 1 , Yao Li 1 , Ming-Ze Su 1 , Qiang-Yi Wang 1 , Xi-Zhan Xu 1 , Juan Deng 1 , Hui Zhuang 1 , Tong Li 1
Affiliation  

High genetic variability at the reverse transcriptase (RT) region of HBV could confer resistance to nucleoside/nucleotide analogues (NUCs). The aim of this study was to identify new RT amino acid (AA) substitutions related to NUC resistance.

中文翻译:

HBV rtH55R聚合酶取代对病毒复制和rtM204I / V对核苷/核苷酸抗病毒药物的耐药性的影响。

HBV逆转录酶(RT)区域的高遗传变异性可能赋予对核苷/核苷酸类似物(NUCs)的抗性。这项研究的目的是确定与NUC抗性有关的新的RT氨基酸(AA)替代。
更新日期:2020-08-21
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