A large number of literature has shown that high expression of X inactive-specific transcript (XIST) is associated with poor prognosis and metastasis of cancer in patients. However, most of this literature is limited by the small sample sizes and discrete outcomes. Therefore, a meta-analysis was performed to investigate the relation between XIST expression and tumor node metastasis (TNM) stage, lymph node metastasis, distant metastasis, and overall survival of cancer patients. We searched for literature in PubMed, Embase, and Web of Science. The pooled hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the association of XIST expression with prognosis and clinicopathological characteristics of cancer patients. Finally, a total of 14 articles involving 1123 patients were included in this meta-analysis. The results suggested that high expression of XIST has a significant relationship with a relatively poor overall survival for patients with malignant tumors (HR 1.82; 95% CI 1.32, 2.52; P = 0.0003). Moreover, high expression of XIST was significantly associated with poor TNM stage (OR 3.64; 95% CI 2.62, 5.07; P < 0.0001), lymph node metastasis (OR 2.39; 95% CI 1.65, 3.46; P < 0.0001) and distant metastasis (OR 2.84; 95% CI 1.90, 4.23; P < 0.0001). In conclusion, high expression of lncRNA XIST may be a predictive factor of poor prognosis in human cancers.

中文翻译：

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较长的非编码RNA XIST表达作为人类癌症的预后因素：一项荟萃分析。

大量文献表明，X失活特异性转录本（XIST）的高表达与患者癌症的预后和转移不良有关。但是，大多数文献受到样本量小和结果离散的限制。因此，进行了一项荟萃分析，以研究XIST表达与肿瘤节点转移（TNM）阶段，淋巴结转移，远处转移以及癌症患者总体生存之间的关系。我们在PubMed，Embase和Web of Science中搜索文献。计算具有95％置信区间（CI）的合并危险比（HR）或优势比（OR），以评估XIST表达与癌症患者的预后和临床病理特征之间的关联。最后，该荟萃分析共纳入14篇文章，涉及1123名患者。结果表明，XIST的高表达与恶性肿瘤患者相对较差的总体生存率有显着相关性（HR 1.82； 95％CI 1.32，2.52； P = 0.0003）。此外，XIST的高表达与TNM分期差（OR 3.64; 95％CI 2.62，5.07; P <0.0001），淋巴结转移（OR 2.39; 95％CI 1.65，3.46; P <0.0001）和远处转移显着相关（OR 2.84； 95％CI 1.90，4.23； P <0.0001）。总之，lncRNA XIST的高表达可能是人类癌症预后不良的预测因素。此外，XIST的高表达与TNM分期差（OR 3.64; 95％CI 2.62，5.07; P <0.0001），淋巴结转移（OR 2.39; 95％CI 1.65，3.46; P <0.0001）和远处转移显着相关（OR 2.84； 95％CI 1.90，4.23； P <0.0001）。总之，lncRNA XIST的高表达可能是人类癌症预后不良的预测因素。此外，XIST的高表达与TNM分期差（OR 3.64; 95％CI 2.62，5.07; P <0.0001），淋巴结转移（OR 2.39; 95％CI 1.65，3.46; P <0.0001）和远处转移显着相关（OR 2.84； 95％CI 1.90，4.23； P <0.0001）。总之，lncRNA XIST的高表达可能是人类癌症预后不良的预测因素。