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A new prenylated coumarin and a new anthranilamide derivative from Evodia lepta.
Journal of Asian Natural Products Research ( IF 1.7 ) Pub Date : 2019-09-30 , DOI: 10.1080/10286020.2019.1670169
Xing-Lin Xie 1 , Guo-Hua Ye 2 , Jun-Juan Xue 2 , Tong Su 1 , Gui-Hua Tang 1 , Wei Li 1 , Sheng Yin 1
Affiliation  

A new prenylated coumarin (1) and a new anthranilamide derivative (2) were isolated from the aerial parts of Evodia lepta. Compound 2 represents the first anthranilamide derivative from the Evodia genus. Their structures were elucidated by spectroscopic data analysis (MS, UV, IR, and NMR). Compound 1 exhibited certain inhibition on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.7 macrophages with an IC50 value of 37.96 ± 1.7 μM.

中文翻译:

Evodia lepta的一种新的烯丙基香豆素和一种新的蒽酰胺衍生物。

从吴茱E的地上部分中分离出新的烯丙基香豆素(1)和新的蒽酰胺衍生物(2)。化合物2代表来自Evodia属的第一个邻氨基苯甲酰胺衍生物。通过光谱数据分析(MS,UV,IR和NMR)阐明了它们的结构。化合物1对RAW264.7巨噬细胞中的脂多糖(LPS)诱导的一氧化氮(NO)生成具有一定的抑制作用,IC50值为37.96±1.7μM。
更新日期:2020-04-20
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