In humans, Lassa virus infection can result in disease with hemorrhagic manifestations and high fatality rates. There are no approved treatments or vaccines available and the inherent danger of studying Lassa virus means it can only be studied in high containment labs (BSL4). Under these conditions, mouse models are becoming an important instrument in the study of Lassa virus infection, disease and host responses. While guinea pigs and non-human primates are the critical components in assessing treatments and vaccines and have recently been used with great affect in this capacity.

中文翻译：

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拉沙病毒感染的动物模型。

在人类中，拉沙病毒感染可导致具有出血表现和高死亡率的疾病。目前尚无批准的治疗方法或疫苗，研究拉沙病毒的固有危险意味着只能在高隔离实验室（BSL4）中进行研究。在这些条件下，小鼠模型已成为研究拉沙病毒感染，疾病和宿主反应的重要工具。豚鼠和非人类灵长类动物是评估治疗和疫苗的关键组成部分，最近已在这种能力中发挥了巨大作用。