Previous studies indicate high prevalence of liver diseases in HIV-infected patients, and their genetic risk factors are still unclear. The chemokine CXCL12 plays important roles in development of chronic liver injury and a single nucleotide polymorphism (SNP) G to A change at position 801 in CXCL12 gene has been demonstrated to affect CXCL12 production levels.

中文翻译：

---

一项横断面研究显示，CXCL12 G801A基因多态性与HIV感染的泰国人中明显的肝纤维化有关。

先前的研究表明，HIV感染患者的肝病患病率很高，其遗传危险因素仍不清楚。趋化因子CXCL12在慢性肝损伤的发展中起重要作用，并且已证明CXCL12基因801位的单核苷酸多态性（SNP）G变为A会影响CXCL12的生产水平。