Nanoparticle-based therapeutics delivery holds great promise for the treatment of intractable diseases. The high loading of drug molecules and their precise delivery to target sites are needed to gain optimal therapeutic functions of the nanoparticle delivery system. In this communication, we highlight, among other properties of nanoparticles (e.g. size, shape, surface chemistry, and degradation), the nanoscale topography, which has recently been shown to be an important parameter, ultimately determining drug loading, cell penetration, and body clearance. This nanotopographical aspect is considered to offer a new effective strategy to the development of nanoparticles for drug and gene delivery with enhanced therapeutic outcome.

中文翻译：

---

改善治疗递送的纳米粒子开发进展：纳米级地形方面。

基于纳米颗粒的治疗递送对于治疗疑难杂症具有广阔的前景。为了获得纳米颗粒递送系统的最佳治疗功能，需要药物分子的高负载量及其精确递送至靶位点。在本次交流中，我们重点介绍纳米颗粒的其他特性（例如尺寸、形状、表面化学和降解）以及纳米级形貌，最近已证明纳米级形貌是一个重要参数，最终决定药物负载、细胞渗透和体内清除。这种纳米形貌方面被认为为开发用于药物和基因递送的纳米颗粒提供了一种新的有效策略，并增强了治疗效果。