A successful colonization of different compartments of the human host requires multifactorial contacts between bacterial surface proteins and host factors. Extracellular matrix proteins and matricellular proteins such as thrombospondin-1 play a pivotal role as adhesive substrates to ensure a strong interaction with pathobionts like the Gram-positive Streptococcus pneumoniae and Staphylococcus aureus. The human glycoprotein thrombospondin-1 is a component of the extracellular matrix and is highly abundant in the bloodstream during bacteremia. Human platelets secrete thrombospondin-1, which is then acquired by invading pathogens to facilitate colonization and immune evasion. Gram-positive bacteria express a broad spectrum of surface-exposed proteins, some of which also recognize thrombospondin-1. This review highlights the importance of thrombospondin-1 as an adhesion substrate to facilitate colonization, and we summarize the variety of thrombospondin-1-binding proteins of S. pneumoniae and S. aureus.

中文翻译：

---

人类血小板反应蛋白1对革兰氏阳性细菌发病的贡献。

人宿主不同区室的成功定殖需要细菌表面蛋白和宿主因子之间的多因素接触。细胞外基质蛋白和基质细胞蛋白（例如血小板反应蛋白1）作为粘附底物起着关键作用，以确保与病原体（如革兰氏阳性肺炎链球菌和金黄色葡萄球菌）发生强烈相互作用。人糖蛋白血小板反应蛋白1是细胞外基质的组成部分，在菌血症期间血流中含量很高。人血小板分泌血小板反应蛋白-1，然后入侵病原体以促进定植和逃避免疫。革兰氏阳性细菌表达广泛的表面暴露蛋白，其中一些还识别血小板反应蛋白-1。