Protein tyrosine phosphorylation is a potent post-translational regulatory mechanism necessary for maintaining normal physiological functioning of immune cells and it is under the stringent control of antagonizing actions of Protein tyrosine phosphatases and kinases. Two such important Non-Receptor protein tyrosine phosphatases, SHP-1 and SHP-2, have been found to be expressed in immune cells and reported to be key regulators of immune cell development, functions, and differentiation by modulating the duration and amplitude of the downstream cascade transduced via receptors. They also have been conceded as the immune checkpoints & therapeutic targets and hence, it is important to understand their significance intricately. This review compares the roles of these two important cytoplasmic PTPs, SHP1 & SHP-2 in the regulation of peripheral as well as central immunity.

中文翻译：

---

外周和中枢免疫的调节：了解Src同源2域酪氨酸磷酸酶SHP-1和SHP-2的作用。

蛋白质酪氨酸磷酸化是维持免疫细胞正常生理功能所必需的有效的翻译后调节机制，并且在蛋白质酪氨酸磷酸酶和激酶的拮抗作用的严格控制下。已发现两种此类重要的非受体蛋白酪氨酸磷酸酶SHP-1和SHP-2在免疫细胞中表达，并据报道是通过调节免疫细胞的持续时间和振幅来调节免疫细胞发育，功能和分化的关键调节剂。通过受体转导的下游级联。它们也被认为是免疫检查点和治疗靶标，因此，重要的是要了解它们的重要性。这篇综述比较了这两个重要的细胞质PTP（SHP1和