Formation of signaling complexes is crucial for the orchestration of fast, efficient, and specific signal transduction. Pharmacological disruption of defined signaling complexes has the potential for specific intervention in selected regulatory pathways without affecting organism-wide disruption of parallel pathways. Signaling by epinephrine and norepinephrine through α and β adrenergic receptors acts on many signaling pathways in many cell types. Here, we initially provide an overview of the signaling complexes formed between the paradigmatic β2 adrenergic receptor and two of its most important targets, the L-type Ca2+ channel CaV1.2 and the AMPA-type glutamate receptor. Importantly, both complexes contain the trimeric Gs protein, adenylyl cyclase, and the cAMP-dependent protein kinase, PKA. We then discuss the functional implications of the formation of these complexes, how those complexes can be specifically disrupted, and how such disruption could be utilized in the pharmacological treatment of disease.

中文翻译：

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具有L型Ca2 +通道CaV1.2和AMPA型谷氨酸受体的β2肾上腺素受体复合物：蛋白质相互作用的药理靶向范例。

信号复合物的形成对于快速，高效和特定信号转导的编排至关重要。定义的信号复合物的药理学破坏可能会在选定的调控途径中进行特定干预，而不会影响整个生物体对平行途径的破坏。肾上腺素和去甲肾上腺素通过α和β肾上腺素能受体的信号传导作用在许多细胞类型中的许多信号传导途径上。在这里，我们首先概述了范式β2肾上腺素能受体与其两个最重要的靶标之间形成的信号复合物，即L型Ca2 +通道CaV1.2和AMPA型谷氨酸受体。重要的是，两种复合物均包含三聚体Gs蛋白，腺苷酸环化酶和cAMP依赖性蛋白激酶PKA。