Long noncoding RNA (lncRNA) H19, a well-known oncogenic lncRNA, is overexpressed in various cancers. Several studies have investigated the association between polymorphisms in lncRNA H19 and the risk of various cancer types; however, the findings were inconsistent. In this study, we performed a meta-analysis to identify the precise association between H19 polymorphisms and cancer risk. Appropriate studies were retrieved from searching Web of Science, PubMed, Scopus, and Google scholar databases, updated 25 November 2018. The pooled odds ratios (ORs with 95% confidence intervals (CIs) were calculated to estimate the strength of the association between H19 polymorphisms and cancer risk. Our findings revealed that the H19-rs217727 C>T polymorphism is significantly associated with an increased risk of overall cancer in homozygous codominant (OR=1.28, 95% CI=1.04-1.57, P =0.020, TT vs CC), dominant (OR=1.20, 95% CI=1.04-1.37, P =0.010, CT+TT vs CC), recessive (OR=1.21, 95% CI=1.00-1.46, P =0.048, TT vs CT+CC), and allele (OR=1.16, 95% CI=1.05-1.28, P =0.003, T vs C) genetic models. No significant correlations were observed between H19: rs2839698 G>A, rs2107425 C>T, rs2735971 C>T, rs3024270 G>C, rs3741219 T>C, rs2839701 C>G, rs2735469 C>T, rs17658052 G>A, and rs3741216 T>A polymorphisms and overall cancer risk. Stratified analysis by cancer type proposed that the rs217727 variant is associated with increased risk of oral squamous cell carcinoma (OSCC) and lung cancer, whereas the rs2839698 variant is associated with increased risk of gastrointestinal cancer. Taken together, these findings support an association between H19 rs217727, and rs2839698 polymorphisms and cancer susceptibility. Larger and well-designed studies are necessary to further confirm these findings in detail.

中文翻译：

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长非编码RNA H19基因多态性与癌症风险之间的关联：一项荟萃分析。

长的非编码RNA（lncRNA）H19是一种众所周知的致癌lncRNA，在各种癌症中均过表达。多项研究调查了lncRNA H19多态性与多种癌症类型之间的关系。但是，结果不一致。在这项研究中，我们进行了荟萃分析，以确定H19多态性与癌症风险之间的确切关联。从2018年11月25日更新的搜索Web of Science，PubMed，Scopus和Google Scholar数据库中检索了适当的研究。计算合并的优势比（OR为95％置信区间（CI）的OR）以估计H19多态性之间的关联强度我们的研究结果表明，在纯合子优势基因中，H19-rs217727 C> T多态性与总体癌症风险增加显着相关（OR = 1。28，95％CI = 1.04-1.57，P = 0.020，TT vs CC），显性（OR = 1.20，95％CI = 1.04-1.37，P = 0.010，CT + TT vs CC），隐性（OR = 1.21， 95％CI = 1.00-1.46，P = 0.048，TT vs CT + CC）和等位基因（OR = 1.16，95％CI = 1.05-1.28，P = 0.003，T vs C）遗传模型。在H19之间未观察到显着相关性：rs2839698 G> A，rs2107425 C> T，rs2735971 C> T，rs3024270 G> C，rs3741219 T> C，rs2839701 C> G，rs2735469 C> T，rs17658052 G> A和rs3741216 T> A多态性与整体癌症风险。按癌症类型进行的分层分析表明，rs217727变异与口腔鳞状细胞癌（OSCC）和肺癌的风险增加有关，而rs2839698变异与胃肠道癌的风险增加有关。综上所述，这些发现支持H19 rs217727，和rs2839698多态性与癌症易感性。为了进一步详细证实这些发现，有必要进行规模较大且设计合理的研究。