Abstract The combination of low dose of radiation and an anticancer drug is a potent strategy for cancer therapy. Nucleoside analogs are known to have a radiosensitizing effects via the inhibition of DNA damage repair after irradiation. Certain types of nucleoside analogs have the inhibitory effects on RNA synthesis, but not DNA synthesis, with multiple functions in cell cycle modulation and apoptosis. In this review, the most up-to-date findings regarding radiosensitizing nucleoside analogs will be discussed, focusing especially on the mechanisms of action.

中文翻译：

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核苷类似物作为放射增敏剂调节 DNA 修复、细胞周期检查点和细胞凋亡

摘要 低剂量辐射与抗癌药物联合使用是一种有效的癌症治疗策略。已知核苷类似物通过抑制辐射后 DNA 损伤修复而具有放射增敏作用。某些类型的核苷类似物对 RNA 合成有抑制作用，但对 DNA 合成没有抑制作用，在细胞周期调节和细胞凋亡方面具有多种功能。在这篇综述中，将讨论关于放射增敏核苷类似物的最新发现，特别关注作用机制。