BACKGROUND AND OBJECTIVE Low serum levels of bilirubin and albumin are associated with multiple autoimmune diseases, but their role in anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is unknown. METHODS Serum bilirubin and albumin levels were evaluated in 60 patients with anti-NMDAR encephalitis, 50 cryptococcal encephalitis, and 145 healthy controls (CTLs). Of the 60 anti-NMDAR encephalitis patients, 30 had a follow-up evaluation at 3 months after admission. RESULTS Serum bilirubin and albumin levels were both significantly lower in anti-NMDAR encephalitis than in CTLs, and serum bilirubin levels were significantly lower in anti-NMDAR encephalitis than in cryptococcal encephalitis. Serum bilirubin levels were significantly lower in patients with psychiatric symptoms, with severe impairment, and with limited responses to treatment than those without psychiatric symptoms, with mild impairment, and with favorable responses to treatment, respectively. A follow-up evaluation of 30 patients revealed that the modified Rankin Scale scores were significantly decreased after treatment. Serum bilirubin significantly associated with serum albumin, and plasma hemoglobin. CONCLUSIONS Our results revealed for the first time an association between the serum levels of bilirubin in the anti-NMDAR encephalitis. Further studies investigating the role of bilirubin and albumin in anti-NMDAR encephalitis are required.

中文翻译：

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抗N-甲基-D-天冬氨酸受体脑炎的血清胆红素和白蛋白。

背景与目的血清胆红素和白蛋白水平低与多种自身免疫性疾病有关，但它们在抗N-甲基-D-天冬氨酸受体（抗NMDAR）脑炎中的作用尚不清楚。方法对60例抗NMDAR脑炎，50例隐球菌性脑炎和145例健康对照（CTL）患者进行血清胆红素和白蛋白水平评估。在60例抗NMDAR脑炎患者中，有30例在入院后3个月进行了随访评估。结果抗NMDAR脑炎的血清胆红素和白蛋白水平均显着低于CTL，抗NMDAR脑炎的血清胆红素水平显着低于隐球菌脑炎。有严重精神障碍的精神病症状患者的血清胆红素水平显着降低，与没有精神症状，轻度损害和对治疗的反应相比，对治疗的反应较有限。对30例患者进行的随访评估显示，治疗后改良的Rankin量表评分明显降低。血清胆红素与血清白蛋白和血浆血红蛋白显着相关。结论我们的结果首次揭示了抗NMDAR脑炎的血清胆红素水平之间存在关联。需要进一步研究胆红素和白蛋白在抗NMDAR脑炎中的作用。对30例患者进行的随访评估显示，治疗后改良的Rankin量表评分明显降低。血清胆红素与血清白蛋白和血浆血红蛋白显着相关。结论我们的结果首次揭示了抗NMDAR脑炎的血清胆红素水平之间存在关联。需要进一步研究胆红素和白蛋白在抗NMDAR脑炎中的作用。对30例患者进行的随访评估显示，治疗后改良的Rankin量表评分明显降低。血清胆红素与血清白蛋白和血浆血红蛋白显着相关。结论我们的结果首次揭示了抗NMDAR脑炎的血清胆红素水平之间存在关联。需要进一步研究胆红素和白蛋白在抗NMDAR脑炎中的作用。