OBJECTIVE The role of CXCL12 and its receptor CXCR4 has not been fully examined in Parkinson's disease (PD). The purpose of this study was to investigate the role of CXCL12/CXCR4 in the peripheral blood of patients with PD and healthy controls. METHODS CXCL12 serum levels and CXCR4 mRNA levels were measured in 30 PD patients and 40 controls using ELISA and real-time PCR, respectively. RESULTS CXCL12 serum levels were significantly higher in PD patients compared to controls (p < 0.0001). Moreover, CXCR4 expression in peripheral blood mononuclear cells (PBMC) of PD patients was significantly increased compared to controls (p < 0.0001). CONCLUSIONS Our findings provide new information on the expression of CXCL12/CXCR4 in PD. CXCR4 expression in PBMC or CXCL12 serum levels may be potential biomarkers of inflammation in PD patients.

中文翻译：

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帕金森氏病患者外周血中的CXCL12和CXCR4。

目的在帕金森氏病（PD）中，尚未充分研究CXCL12及其受体CXCR4的作用。这项研究的目的是调查CXCL12 / CXCR4在PD患者和健康对照者外周血中的作用。方法采用ELISA和实时荧光定量PCR分别测定30例PD患者和40例对照者的CXCL12血清水平和CXCR4 mRNA水平。结果与对照组相比，PD患者的CXCL12血清水平显着更高（p <0.0001）。此外，与对照组相比，PD患者的外周血单个核细胞（PBMC）中的CXCR4表达显着增加（p <0.0001）。结论我们的发现为PD中CXCL12 / CXCR4的表达提供了新的信息。PBMC或CXCL12血清中的CXCR4表达可能是PD患者炎症的潜在生物标志物。