OBJECT CD27 belongs to the tumor necrosis factor receptor family and is constitutively expressed on T cells. The concentration of cerebrospinal fluid (CSF) soluble (s)CD27 is elevated in patients with multiple sclerosis (MS). However, whether the level of CSF sCD27 is elevated in neuromyelitis optica spectrum disorder (NMOSD) remains unknown. The aim of this study was to measure the CSF concentration of sCD27 and to determine its relationship with NMOSD disease activity. METHODS CSF CXCL13 was measured by ELISA in neuromyelitis optica (NMO) (n = 31) and MS (n = 23) patients and in controls (CTLs) (n = 22). RESULTS The concentration of sCD27 was higher in the NMO group than in the MS (p = 0.082) and CTL (p = 0.002) groups, and there was a positive correlation with CSF IL-6 (p = 0.000) and a negative correlation with IL-10 (p = 0.073). In the NMO group, patients with higher sCD27 concentrations exhibited worse disease disability in their CSF (p = 0.006). Moreover, the sCD27 concentrations had a significantly positive correlation with the level of CSF total protein (p = 0.030). Furthermore, the patients positive for AQP4-IgG (n = 26) seemed to have higher levels of sCD27 in their CSF (p = 0.069) than those negative for AQP4-IgG (n = 5). CONCLUSIONS We revealed that the level of CSF sCD27 was elevated in NMOSD and correlated with NMOSD disease activity.

中文翻译：

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脑脊髓液中可溶性CD27的水平与视神经脊髓炎性光谱障碍中的疾病严重程度有关。

OBJECT CD27属于肿瘤坏死因子受体家族，在T细胞上组成性表达。多发性硬化症（MS）患者的脑脊液（CSF）可溶性（s）CD27浓度升高。然而，在视神经脊髓炎频谱疾病（NMOSD）中，CSF sCD27的水平是否升高尚不清楚。这项研究的目的是测量sCD27的脑脊液浓度，并确定其与NMOSD疾病活动的关系。方法采用ELISA法在视神经脊髓炎（NMO）（n = 31）和MS（n = 23）患者以及对照组（CTL）（n = 22）中测定CSF CXCL13。结果NMO组的sCD27浓度高于MS组（p = 0.082）和CTL组（p = 0.002），与CSF IL-6正相关（p = 0.000），与CSF IL-6正相关（p = 0.000）。 IL-10（p = 0.073）。在NMO组中，具有较高sCD27浓度的患者在其CSF中表现出较差的疾病残疾（p = 0.006）。此外，sCD27浓度与脑脊液总蛋白水平呈显着正相关（p = 0.030）。此外，AQP4-IgG阳性的患者（n = 26）似乎比AQP4-IgG阴性的患者（n = 5）的脑脊液中sCD27水平更高（p = 0.069）。结论我们揭示了NMOSD中CSF sCD27的水平升高，并且与NMOSD疾病活动相关。AQP4-IgG阳性（n = 26）的患者的脑脊液中sCD27水平似乎较高（p = 0.069），而AQP4-IgG阴性的患者（n = 5）更高。结论我们揭示了NMOSD中CSF sCD27的水平升高，并且与NMOSD疾病活动相关。AQP4-IgG阳性（n = 26）的患者的脑脊液中sCD27水平似乎较高（p = 0.069），而AQP4-IgG阴性的患者（n = 5）更高。结论我们揭示了NMOSD中CSF sCD27的水平升高，并且与NMOSD疾病活动相关。