Recent data have suggested that failure to achieve sustained virological response with direct-acting antiviral therapy is usually due to relapse and is primarily associated with the emergence of resistance-associated substitutions. The aim of this study was to investigate the prevalence and characterization of non-structural-5A resistance-associated substitutions in patients infected with HCV genotypes 1, 3 and 4 treated by direct-acting antiviral therapy, including anti-non-structural-5A, and to characterize the pre-existing resistance-associated substitutions in subjects treated with anti-non-structural-5A inhibitors.

中文翻译：

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来自多中心现实生活队列的复发患者的基线和治疗后丙型肝炎 NS5A 耐药性。

最近的数据表明，直接抗病毒治疗未能实现持续的病毒学应答通常是由于复发，并且主要与耐药相关替代物的出现有关。本研究的目的是调查接受直接抗病毒治疗（包括抗非结构 5A、抗非结构 5A、并描述用抗非结构 5A 抑制剂治疗的受试者中预先存在的与耐药性相关的替代。