The association between detected drug resistance mutations and CD4+ T-cell decline in HIV-positive individuals maintained on a failing treatment regimen.,Antiviral Therapy

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The association between detected drug resistance mutations and CD4+ T-cell decline in HIV-positive individuals maintained on a failing treatment regimen.
Antiviral Therapy ( IF 1.3 ) Pub Date : 2017-6-20 , DOI: 10.3851/imp3178
Anna Schultze ₁ , Roger Paredes ₂ , Caroline Sabin ₁ , Andrew N Phillips ₁ , Deenan Pillay _{3,

4} , Nicola Mackie ₅ , Antonella Castagna ₆ , David Chadwick ₇ , Karolin Falconer ₈ , Anna Maria Geretti ₉ , Frank A Post ₁₀ , Teresa Hill ₁ , Ole Kirk ₁₁ , Anton Pozniak ₁₂ , Mark Nelson ₁₂ , Anna Tostevin ₁ , David Dunn _{1,

13} , Jens Lundgren ₁₁ , Alessandro Cozzi-Lepri ₁

Affiliation

Department of Infection and Population Health, UCL, London, UK.
Institut de Recerca de la SIDA-IrsiCaixa, Badalona, Spain.
Division of Infection and Immunity, UCL, London, UK.
Africa Centre for Population Health, University of KwaZulu-Natal, KwaZulu-Natal, South Africa.
Department of HIV, Sexual Health and Infections, Imperial College Healthcare NHS Trust, London, UK.
Università Vita-Salute San Raffaele, Milan, Italy.
Centre for Clinical Infection, James Cook University Hospital, Middlesbrough, UK.
Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.
Department of Sexual Health and HIV, King's College Hospital, London, UK.
Department of Infectious Diseases, CHIP, Section 2100, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
St Stephens AIDS Trust, Chelsea and Westminster Hospital, London, UK.
MRC Clinical Trials Unit, UCL, London, UK.

To analyse the effect of drug resistance mutations (DRM) on CD4⁺ T-cell (CD4) trends in HIV-positive people maintained on virologically failing antiretroviral therapy (ART).

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