Glyphosate tolerant soybeans represent a large portion of soybeans grown and fed to farm animals around the world. Despite their widespread use for many years, some have raised questions regarding their safety because the soybeans were genetically modified. The CP4 EPSPS gene which imparts resistance to topical application of the herbicide glyphosate was introduced into soybeans. Application of glyphosate to soybean fields will reduce weed pressure and increase soybean yield. To assess their safety on the rat reproduction system, male Sprague Dawley rats were fed either glyphosate-tolerant (GM) soybean (40-3-2) or near-isogenic, non-GM (A5403) (control) soybean meal. The processed soybean meal was added to formulated rodent diets at 20% (w/w) and fed to rats for 90 days. Some rats from the control group were separately administered mitomycin C for 40 days and served as positive controls in the sperm abnormality test. Body weights and behavior were monitored daily, serum enzymes and histologic and EM appearance of the testis, and sperm morphology were also examined. After 90 days of feeding, no adverse effects were observed in rats fed glyphosate-tolerant soybeans.

中文翻译：

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评估饲喂耐草甘膦大豆 (CP4 EPSPS) 对雄性 Sprague-Dawley 大鼠睾丸的影响。


耐草甘膦大豆占世界各地种植和喂养农场动物的大豆的很大一部分。尽管大豆已被广泛使用多年，但由于大豆是转基因大豆，一些人对其安全性提出了质疑。将赋予局部使用除草剂草甘膦抗性的 CP4 EPSPS 基因引入大豆中。在大豆田施用草甘膦可以减少杂草压力并提高大豆产量。为了评估其对大鼠生殖系统的安全性，雄性斯普拉道利大鼠喂食耐草甘膦 (GM) 大豆 (40-3-2) 或近等基因的非转基因 (A5403)（对照）豆粕。将加工后的豆粕以 20%（w/w）添加到配制的啮齿动物饲料中，并喂给大鼠 90 天。对照组大鼠单独给予丝裂霉素C 40天，作为精子异常试验的阳性对照。每天监测体重和行为，还检查血清酶、睾丸的组织学和电镜外观以及精子形态。饲喂 90 天后，在饲喂耐草甘膦大豆的大鼠中没有观察到任何不良反应。