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Opportunities in Novel Psychotropic Drug Design from Natural Compounds.
International Journal of Neuropsychopharmacology ( IF 4.5 ) Pub Date : 2019-09-01 , DOI: 10.1093/ijnp/pyz042
Siu Wa Tang 1, 2 , Wayne H Tang 1
Affiliation  

Multiple initiatives at the national and international level support natural drug discovery. Psychiatrists and patients are not well informed about natural psychotropics in general. Existing antidepressant and antipsychotic drugs were developed from atropine, a natural product. Subsequent drug developments were largely based on extension and modification of earlier molecular scaffolds. This limits their mechanisms of action to similar neuropathways. Natural psychotropic substances, particularly those with hallucinogenic and psychedelic properties and different chemical structures, may serve as new paths to novel psychotropic drug development.

中文翻译:

来自天然化合物的新型精神药物设计的机会。

国家和国际一级的多项倡议支持天然药物的发现。一般而言,精神科医生和患者对自然精神疗法知之甚少。现有的抗抑郁药和抗精神病药是从天然产品阿托品开发出来的。随后的药物开发主要基于早期分子支架的扩展和修饰。这将它们的作用机制限制在相似的神经通路上。天然精神药物,尤其是具有致幻和迷幻性质且化学结构不同的药物,可作为新型精神药物开发的新途径。
更新日期:2019-11-01
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