From several decades ago to now, cancer continues to be the leading cause of death worldwide, and metastasis is the major cause of cancer-related deaths. For health benefits, there is a great desire to use non-chemical therapy such as nutraceutical supplementation to prevent pathology development. Over 10,000 different natural bioactives or phytochemicals have been known that possessing potential preventive or supplementary effects for various diseases including cancer. Previously, the in vitro and in vivo anti-invasive and anti-metastatic activities of phenolic acids, monophenol, polyphenol and their derivatives and flavonoids and their derivatives have been reviewed. However, a vast number of natural dietary compounds other than phenolics have been demonstrated to potentially possess the ability to inhibit the invasion and metastasis of various cancers. In this review, we summarize the studies in recent decade on in vitro and in vivo effects and molecular mechanisms of natural bioactives, excluding the phenolics in food, in cancer invasion and metastasis. By combining this review of non-phenolics with the previous phenolics reviews, the puzzle for the contribution of natural dietary bioactives on cancer invasive or/and metastatic progress will be almost complete and more clear.

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天然膳食非酚类生物活性物质对癌症转移的最新进展

从几十年前到现在，癌症仍然是全球死亡的主要原因，而转移是癌症相关死亡的主要原因。为了健康益处，人们非常希望使用非化学疗法（例如营养补充剂）来预防病理发展。已知超过 10,000 种不同的天然生物活性物质或植物化学物质对包括癌症在内的各种疾病具有潜在的预防或补充作用。此前，对酚酸类、单酚类、多酚类及其衍生物和黄酮类及其衍生物的体外和体内抗侵袭和抗转移活性进行了综述。然而，除酚类物质外，大量天然膳食化合物已被证明具有潜在的抑制各种癌症侵袭和转移的能力。在这篇综述中，我们总结了近十年来关于天然生物活性物质（不包括食物中的酚类物质）在癌症侵袭和转移中的体外和体内作用和分子机制的研究。通过将本次非酚类物质综述与之前的酚类物质综述相结合，天然膳食生物活性物质对癌症侵袭性或/和转移性进展的贡献的难题将几乎完整且更加清晰。