Hepatitis E virus (HEV) can induce chronic infections in the case of immunosuppression, which are sometimes not cured with ribavirin. Furthermore, sofosbuvir is a highly potent inhibitor of HCV polymerase and was shown to inhibit HEV genotype-3 replication in vitro. We report here the outcome of sofosbuvir/ribavirin therapy on a chronic HEV infection in a heart transplant recipient non-responder to ribavirin. After 24 weeks, the regimen failed to cure the persistent HEV infection, highlighting the need of therapeutic options for HEV-infected immunosuppressed patients.

中文翻译：

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心脏移植患者的慢性戊型肝炎：索非布韦和利巴韦林治疗方案无效。

在免疫抑制的情况下，戊型肝炎病毒（HEV）可以诱导慢性感染，有时不能用利巴韦林治愈。此外，sofosbuvir是HCV聚合酶的高效抑制剂，并显示在体外抑制HEV基因型3的复制。我们在这里报告索非布韦/利巴韦林疗法对心脏移植受者无应答的慢性HEV感染的结果。24周后，该方案未能治愈持续性的HEV感染，这凸显出需要针对HEV感染的免疫抑制患者的治疗选择。