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Long-term persistence of HCV NS5A resistance-associated substitutions after treatment with the HCV NS5A inhibitor, ledipasvir, without sofosbuvir.
Antiviral Therapy ( IF 1.3 ) Pub Date : 2017-6-27 , DOI: 10.3851/imp3181
David Wyles 1 , Alessandra Mangia 2 , Wendy Cheng 3 , Stephen Shafran 4 , Christian Schwabe 5 , Wen Ouyang 6 , Charlotte Hedskog 6 , John McNally 6 , Diana M Brainard 6 , Brian P Doehle 6 , Evguenia Svarovskaia 6 , Michael D Miller 6 , Hongmei Mo 6 , Hadas Dvory-Sobol 6
Affiliation  

Data on persistence of NS5A resistance-associated substitutions (RASs) may have implications for resistance testing approaches and selection of initial and retreatment strategies.

中文翻译:

用 HCV NS5A 抑制剂 ledipasvir 治疗后长期持续存在 HCV NS5A 耐药性相关替代,而不使用索非布韦。

NS5A 耐药相关替代物 (RAS) 持续存在的数据可能对耐药性测试方法以及初始和再治疗策略的选择产生影响。
更新日期:2020-08-21
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