AIM To evaluate the effect blepharitis lid cleansers have on the tear film and ocular surface, and to examine the prevalence of Demodex folliculorum in a young population. METHODS Forty-eight university students completed a randomised, controlled, investigator-masked, eight-week clinical trial. Three eyelid hygiene products were investigated: blepharitis eyelid cleanser (OCuSOFT® Lid Scrub® PLUS foam), diluted baby shampoo (10% Johnson's® No More Tears ®) and a tea-tree based face wash (dr.organic®). Cooled boiled water was used as a control. Subjects attended for four visits: baseline, two weeks, four weeks and eight weeks. At each visit, subjective symptoms, non-invasive tear break up time, ocular surface staining and Demodex folliculorum investigation were assessed to evaluate any positive or negative effect on the tear film and ocular surface. Osmolarity was also measured at baseline and week eight only. RESULTS The overall prevalence of Demodex folliculorum found at baseline was 15%. Subjective symptoms improved in all groups, including control. There was no significant difference in mean osmolarity between the groups or within each group after eight weeks. There was a significant increase in osmolarity inter-eye variability in the baby shampoo group (5.5 ± 5.4 vs 15.2 ± 9.5; p = 0.03). There was no significant change in non-invasive tear break up time or ocular surface staining demonstrated after eight weeks of eyelid hygiene. CONCLUSION A low prevalence of Demodex folliculorum can be found in a young population. All blepharitis lid cleansers used demonstrated subjective improvement in symptoms, with no negative effects on tear break-up time or ocular surface staining. The blepharitis eyelid cleanser and tea-tree based face wash revealed no adverse effect on mean osmolarity or inter-eye variability. Similarly, baby shampoo did not cause a significant increase in mean osmolarity, however, a significant increase in inter-eye variability was found; suggesting a possible increase in ocular surface inflammation.

中文翻译：

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眼睑卫生对泪膜和眼表的影响以及大学生蠕形螨眼睑缘炎的患病率。

目的评估睑缘炎眼睑清洁剂对泪膜和眼表的影响，并检查蠕形螨在年轻人口中的患病率。方法48名大学生完成了一项随机，对照，研究者掩盖的为期八周的临床试验。研究了三种眼睑卫生产品：睑缘炎眼睑清洁剂（OCuSOFT®LidScrub®PLUS泡沫），稀释的婴儿洗发水（10％Johnson's®No MoreTears®）和基于茶树的洗面奶（dr.organic®）。冷却的开水用作对照。受试者参加了四次探访：基线，两周，四周和八周。每次就诊时，主观症状，无创眼泪破裂时间，评估了眼表染色和蠕形螨的研究，以评估对泪膜和眼表的任何正面或负面影响。还仅在基线和第八周测量了渗透压。结果在基线时发现蠕形螨的总患病率为15％。所有组的主观症状均得到改善，包括对照组。8周后，各组之间或各组内的平均渗透压没有显着差异。婴儿洗发水组的渗透压眼内变异性显着增加（5.5±5.4对15.2±9.5； p = 0.03）。八周眼睑卫生后，无创撕裂时间或眼表染色无明显变化。结论在年轻人口中蠕形螨的患病率较低。使用的所有睑缘炎眼睑清洁剂均显示出主观症状改善，对泪液破裂时间或眼表染色没有负面影响。睑缘炎眼睑清洁剂和茶树基洗脸液对平均渗透压或眼间变异性没有不利影响。同样，婴儿洗发水的平均渗透压没有明显增加，但是眼内变异性却显着增加。提示眼表炎症可能增加。婴儿洗发水的平均渗透压没有明显增加，但是，眼间变异性却显着增加；提示眼表炎症可能增加。婴儿洗发水的平均渗透压没有明显增加，但是，眼内变异性却显着增加。提示眼表炎症可能增加。