Understanding why some people continue to drink alcohol despite negative consequences and others do not is a central problem in the study of alcohol use disorder (AUD). In this study, we used alcohol-preferring P rats (a strain bred to prefer to drink alcohol, a model for genetic risk for AUD) and Wistar rats (control) to examine drinking despite negative consequences in the form of an aversive bitter taste stimulus produced by quinine. Animals were trained to consume 10% ethanol in a simple Pavlovian conditioning task that paired alcohol access with an auditory stimulus. When the alcohol was adulterated with quinine (0.1 g/L), P rats continued to consume alcohol + quinine at the same rate as unadulterated alcohol, despite a demonstrated aversion to quinine-adulterated alcohol when given a choice between adulterated and unadulterated alcohol in the home cage. Conversely, Wistar rats decreased consumption of quinine-adulterated alcohol in the task, but continued to try the alcohol + quinine solution at similar rates to unadulterated alcohol. These results indicate that following about 8 weeks of alcohol consumption, P rats exhibit aversion-resistant drinking. This model could be used in future work to explore how the biological basis of alcohol consumption and genetic risk for excessive drinking lead to drinking that is resistant to devaluation.

中文翻译：

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偏爱酒精的P大鼠表现出对掺有奎宁的酒精的厌恶饮用。

在酒精滥用障碍（AUD）研究中，了解为什么有些人尽管有不良后果而仍继续喝酒而其他人却不喝酒是一个中心问题。在这项研究中，我们使用了偏爱酒精的P大鼠（繁殖出更喜欢饮酒的品系，一种用于AUD的遗传风险模型）和Wistar大鼠（对照）来检查饮酒，尽管这些饮料以厌恶性苦味刺激的形式产生了不良后果由奎宁生产。训练动物在简单的巴甫洛夫式调理任务中消耗10％的乙醇，该任务将酒精获取与听觉刺激配对。当酒精掺入奎宁（0.1 g / L）时，P大鼠继续以与未掺杂酒精相同的速率消耗酒精+奎宁，尽管在家用笼子中在掺假和未掺假的酒精之间进行选择时，已证明对奎宁掺假的酒精有厌恶感。相反，Wistar大鼠在这项任务中减少了奎宁掺杂的酒精的消耗，但继续尝试使用与未经掺杂的酒精相似的速率的酒精+奎宁溶液。这些结果表明，饮酒约8周后，P大鼠表现出抗厌食性饮酒。该模型可用于未来的工作中，以探索酒精消费的生物学基础和过度饮酒的遗传风险如何导致饮酒抗贬值。这些结果表明，饮酒约8周后，P大鼠表现出抗厌食性饮酒。该模型可用于将来的工作中，以探索酒精消费的生物学基础和过度饮酒的遗传风险如何导致饮酒抗贬值。这些结果表明，饮酒约8周后，P大鼠表现出抗厌食性饮酒。该模型可用于将来的工作中，以探索酒精消费的生物学基础和过度饮酒的遗传风险如何导致饮酒抗贬值。