Dewetting transition - a concept borrowed from fluid mechanics - is a physiological process that takes place inside the hydrophobic pores of ion channels. This transient phenomenon causes a metastable state that forbids water molecules to cross microscopic receptor cavities. This leads to a decreased conductance, a closure of the pore and, subsequently, severe impairment of cellular performance. We suggest that artificially-provoked dewetting transition in ion channel hydrophobic pores might stand for a molecular candidate to erase detrimental organisms, such as viruses, bacteria, and cancer cells. We describe a novel type of high-affinity monoclonal antibody, that: a) targets specific trans-membrane receptor structures of harmful or redundant cells; b) is equipped with lipophilic and/or hydrophobic fragments that prevent physiological water flow inside ion channels. Therefore, we achieve an artificial dewetting transition inside receptor cavities, that causes discontinuity within transmembrane ionic flows, channel blockage, and subsequent damage of morbid cells. As an example, we describe dewetting monoclonal antibodies that target the M2 channel of the Influenza A virus: they might prevent water from entering pores thus leading to virion impairment.

去湿过渡-从流体力学中借用的一个概念-是发生在离子通道疏水孔内部的生理过程。这种短暂的现象导致亚稳态，从而禁止水分子穿过微观受体腔。这导致电导降低，孔封闭，随后严重损害细胞性能。我们建议在离子通道疏水孔中人工引发的去湿转变可能代表一种分子候选物，以消除有害生物，例如病毒，细菌和癌细胞。我们描述了一种新型的高亲和力单克隆抗体，它：a）靶向有害或冗余细胞的特定跨膜受体结构；b）配备了亲脂性和/或疏水性片段，可防止生理水在离子通道内部流动。因此，我们实现了受体腔内的人工去湿过渡，这会导致跨膜离子流不连续，通道阻塞以及随后的病态细胞损伤。例如，我们描述了针对A型流感病毒M2通道的去湿性单克隆抗体：它们可以防止水进入毛孔，从而导致病毒体损伤。