As knowledge of the biological processes underlying malignant transformation becomes increasingly sophisticated, apparently similar diseases can be redefined according to the critical disrupted biological pathways and networks. The key genetic changes in most cancers can be mapped to one of a relatively few pathways, making it possible to classify tumours by their abnormal pathways and to identify potentially treatable--'druggable'--targets within these. The aim of the stratified approach to cancer therapy is to improve the effectiveness, tolerability and affordability of novel therapeutic agents.

中文翻译：

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用于癌症治疗的分层药物。

随着对恶性转化潜在生物学过程的了解变得越来越复杂，显然可以根据严重的生物学途径和网络破坏来重新定义相似的疾病。大多数癌症中的关键遗传变化可以映射到相对较少的一种途径中，从而可以通过其异常途径对肿瘤进行分类，并在这些途径中识别出可能可治疗的“可药物性”靶标。癌症治疗的分层方法的目的是提高新型治疗剂的有效性，耐受性和可负担性。